Injectable Polypeptide Hormones Corticotropin CAS 9002-60-2 ACTH for Collagen Diseases
|Purchase Qty. (Pieces)||FOB Price|
|1||US $1 / Piece|
|2||US $2 / Piece|
|3||US $3 / Piece|
|4||US $4 / Piece|
|5+||US $5 / Piece|
Alias : Adrendcorticotrophic hormone, ACTH, ACTH 1-39 , acethropan
CAS NO. : 9002-60-2
MF : C207H308N56O58S
MW : 4541.07
Purity (HPLC): 99%
Appearance: White or light yellow powder, odorless, moisture, soluble in water, soluble in 70% acetone and 70% ethanol
Grade : Pharmaceutical Grade
Storage: Closed, −20°C preservation
Usage : Hormone kind medicine, promote the secretion of adrenal cortical hormone, used in active rheumatism, rheumatoid arthritis, lupus and other collagen diseases. Clinical use of cortisone similar.
This product is composed of 39 amino acid residues, species differences only in the 25-33 position, 1-24 bits of the fragment with all the activity, twenty-fourth amino acid after the part only to maintain stability of the whole polypeptide structure. In the solution is highly - Helical structure. By partial hydrolysis of pepsin is still active.
This product is poor efficacy of oral invalid; intramuscular injection; intravenous injection effect is fast, but has a half-life of only 15min, hold time 1-3h.
Adrenocorticotropic hormone, commonly referred to as ACTH and also known as corticotropin, is a polypeptide hormone produced in and secreted by the anterior pituitary gland. It is a key component in the hypothalamic-pituitary-adrenal axis, often produced in response to exogenous biological stress along with corticotropin-releasing hormone (which is also from the hypothalamus.) Its effects include increased production and release of corticosteroids and, as its name suggests, cortisol from the adrenal cortex.
ACTH acts through the stimulation of cell surface ACTH receptors, which are located primarily on adrenocortical cells of the adrenal cortex. This results in the synthesis and secretion of gluco- and mineralo-corticosteroids and androgenic steroids. The ACTH receptor is a seven-membrane-spanning G protein-coupled receptor. Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A. This ultimately results in stimulation of steroidogenesis. Steroidogenesis. Steroidogenesis is the biological process by which steroids are generated from cholesterol and transformed into other steroids. The pathways of steroidogenesis differ between different species, but the pathways of human steroidogenesis are shown in the figure. Products of steroidogenesis include: androgens testosterone estrogens and progesterone corticoids cortisol aldosterone ACTH acts at several key steps to influence the steroidogenic pathway in the adrenal cortex: ACTH stimulates lipoprotein uptake into cortical cells. This increases the bio-availability of cholesterol in the cells of the adrenal cortex. ACTH increases the transport of cholesterol into the mitochondria and activates its hydrolysis. ACTH Stimulates cholesterol side-chain cleavage enzyme, which makes the rate-limiting step in steroidogenesis. This results in the production of pregnenolone.
Hormone drugs. For epinephrine cortical function diagnosis, prevent atrophy of cortex long-term use of corticosteroids after stopping drug, can also be used for the treatment of some collagen diseases, severe bronchial asthma, epilepsy, myasthenia gravis.
1. Rich experience.
Our company is a professional steroid supplier in China over 15 years.Our products have been exported to Germany, Spain, UK, USA, Canada,Brazil,Australia, Middle East, and others.We got very good feedback from our customers, due to the quality of our steroid and professional experience in operating the business.
2. Great quality, purity and favourable.
Good quality is one of our secret of success,both raw powder and liquid steroids.
3. Safe and fast delivery.
There is also steroids at stock, so we can deliver them very quickly as soon as we got the payment,normally within 24 hours.
We have special way that could ship 0.01kg to 3.5kg products at one time. We also offer melting powder into liquid service.And can ship the liquid in special bottles.
4. Good after-sales service.
Tracking the package and updating it every day.Quick response and good communications,online 24 hours.
|Testosterone Sustanon 250||Null|
|Drostanolone Propionate (Masteron)||Cas.:521-12-0|
|4-Chlorotestosterone Acetate||Cas: 855-19-6|
|Oral turinabol||Cas.: 2446-23-3|
|Methenolone Enanthate (Primobolan)||Cas::303-42-4|
|Clomifene citrate Clomid||Cas:50-41-9|
|Toremifene Citrate||Cas: 89778-27-8|
|L-Epinephrine Hydrochloride||Cas: 55-31-2|
|Epinephrine hydrogen tartrate||Cas:51-42-3|
|Dapoxetine hydrochloride||Cas.: 119356-77-3|
|Yohimbine HCl Extract||Cas: 65-19-0|