Pain Killer Anesthetic Drug Procaine Hydrochloride CAS 51-05-8
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Alias: 2-(Diethylamino)ethyl 4-aminobenzoate; Procaine Hcl; ATOXICAINE; 2-(diethylamino)ethyl 4-aminobenzoate hydrochloride (1:1); 2-methylpropyl 4-aminobenzoate
Characters:White crystal or crystalline powder; odorless, slightly bitter taste, followed by a sense of paralysis. This product is soluble in water, slightly soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether
Melting Point: 155.0~156.0ºC
Molecular Formula:C13H20N2O2 HCl
Role: Effect of procaine hydrochloride block effect generated in the peripheral nerves, relying on the concentration gradient to diffuse way to penetrate the nerve cell membrane, blocking sodium channels on the inside, so that the nerve cell excitability threshold is increased, the loss of excitability and conductivity, information delivery is blocked, with good local anesthetic.
Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.
Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.
Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase, which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.
|Product name||Procaine HCl|
|Appearance||White crystalline powder|
|Assay (C13H20N2O2·HCl)||99.0% to 101.0%||99.50%|
|Acidity||≤0.02N NaOH 0.5ml||0.3ml|
|Chromatographic purity||Secondary spots≤0.5%,sum≤1.0%||Conforms|
|Loss on drying||≤1.0%||0.06%|
|Residue on ignition||≤0.15%||0.03%|
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