High Purity Peptides Tesamorelin 2mg/Vials Stimulating The Pituitary Gland to Release
Super Class; Organic Acids
Class; Carboxylic Acids and Derivatives
Sub Class; Amino Acids, Peptides, and Analogues
Direct Parent; Peptides
Reducing excess stomach fat in certain HIV-infected patients.Tesamorelin is a human -releasing factor analog. It works by stimulating the pituitary gland to release . This causes the breakdown of excess stomach fat.
VAT decreased by -10.9% (-21 cm(2)) in the tesamorelin group vs. -0.6% (-1 cm(2)) in the placebo group in the 6-month efficacy phase, P < 0.0001. Trunk fat (P < 0.001), waist circumference (P = 0.02), and waist-hip-ratio (P = 0.001) improved, with no change in limb or abdominal SC fat. Insulin-like growth factor-1 increased (P < 0.001), but no change in glucose parameters was observed. Patient rating of belly appearance distress (P = 0.02) and physician rating of belly profile (P = 0.02) were significantly improved in the tesamorelin vs. placebo-treated groups. The drug was well tolerated. VAT was reduced by approximately 18% (P < 0.001) in patients continuing tesamorelin for 12 months. The initial improvements over 6 months in VAT were rapidly lost in those switching from tesamorelin to placebo.
Tesamorelin is a stabilized synthetic peptide analogue of the hypothalamic peptide, (GHRH) indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and hyperlipidemia associated with antiretroviral therapy for HIV infection.
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